The accompanying music video was directed by Ramez Silyan and features Rosé and actor Evan Mock in a toxic love story filmed at Old Westbury Gardens, New York.

Rosé made her debut live performance of "Toxic Till the End" on The Tonight Show Starring Jimmy Fallon.

Rosé shared in an interview with Apple Music's The Zane Lowe Show that the track was the result of her need to gain closure about the experience, stating: "We've talked about the ex a bit too much, it's about time that we write a song called 'the ex'."

Writing for Clash, Robin Murray positively labeled "Toxic Till the End" as a song of escape that "bursts with energy".

[15] Jeff Benjamin of Billboard ranked it at number one in his track-by-track album review, praising its emotional depth, power-pop production, and mainstream appeal.

He highlighted its "buoyancy" despite its "destructive details," calling it a moment in Rosé's solo journey where she steps out of her place in Blackpink to fully embrace her individuality.

[6] Similarly, Renowned for Sound's Eleanor Carr highlighted the track as "a memorable listen", complimenting it for its "tongue-in-cheek lyrics" and sarcastic take on a toxic relationship.

[20] In the United States, "Toxic Till the End" debuted at number 90 on the Billboard Hot 100, her third entry on the chart following "On the Ground" and "Apt.".

[24] She later performed a six-song set, which included "Toxic Till the End", at the Japanese music festival GMO Sonic 2025 held at the Saitama Super Arena as a special guest on 26 January.

Drawing inspiration from Gilmore Girls, the cinematic video tells a toxic love story between the two characters, culminating in a bitter and dramatic conclusion.

She is intrigued and gives him a ride, which leads into a rom-com montage of the couple's happy early days, including scenes of them chasing each other through the gardens of a large estate, sharing a tender fireside snuggle, and her signing his cast after he wipes out on his skateboard.