Toxicoscordion was long submerged into the genus Zigadenus, but its separate position in the phylogeny of the Melanthieae has been confirmed.

Following the eating of a plant part there is a burning sensation in the mouth that only lasts a short time.

Several hours later other digestive symptoms develop including watering of the mouth, vomiting, and diarrhea.

In severe cases there may be heart beat irregularities, abnormal blood pressure, coma, or convulsions, potentially followed by death.

Patients are supported with fluid replacement, assistance in breathing if difficulty develops, and medication to manage blood pressure.