She then starred as Charlotte "Charlie" Matheson on the NBC post-apocalyptic science fiction series Revolution from 2012 to 2014, for which she was nominated for a Saturn Award for Best Actress on Television.

[13][14] Spiridakos moved to Vancouver in 2007 to pursue acting, and within weeks landed her first television role, a small part on Supernatural.

She then landed a lead role on the NBC television series Revolution as Charlotte "Charlie" Matheson, a survivalist in a dystopian future civilization.

[18] Spiridakos guest starred on season 3 of the Showtime sitcom, Episodes, as Dawn, a daughter of character Morning Randolph (Mircea Monroe).

[20] Spiridakos began a recurring role on the A&E television drama, Bates Motel in 2015, playing Annika Johnson, a prostitute who arrives at the hotel at the start of the third season.

[21] She will also star opposite Jonathan Rhys Meyers in the romantic comedy Byrd & the Bees, directed by Finola Hughes.