Trandolapril is an ACE inhibitor used to treat high blood pressure.

Side effects reported for trandolapril include nausea, vomiting, diarrhea, headache, dry cough, dizziness or lightheadedness when sitting up or standing, hypotension, or fatigue.

[citation needed] Patients also on diuretics may experience an excessive reduction of blood pressure after initiation of therapy with trandolapril.

[citation needed] Trandolapril is teratogenic (US: pregnancy category D) and can cause birth defects and even death of the developing fetus.

[citation needed] Combination therapy with paricalcitol and trandolapril has been found to reduce fibrosis in obstructive uropathy.