The highest point within the group is the summit of Great Trango Tower at 6,286 m (20,623 ft), the east face of which features the world's greatest nearly vertical drop.

To the north of this feature, the ridge becomes less rocky and loses the large granite walls that distinguish the Trango Towers group and make them so attractive to climbers; however, the summits do get higher.

Overall, the Trango Towers group has seen some of the most difficult and significant big wall climbs ever accomplished, due to the combination of altitude, total height of the routes, and the steepness of the rock.

Trango (Nameless) Tower was first climbed in 1976 by the British climber Joe Brown, along with Mo Anthoine, Martin Boysen, and Malcolm Howells.

Another notable route is Eternal Flame (named after a Bangles song), first climbed on 20 September 1989 by Kurt Albert, Wolfgang Güllich, Milan Sykora, and Christoph Stiegler.

[4] The first female ascent, on 6 September 1990, was achieved in free climbing style, again on the Yugoslav Route, by Catherine Destivelle (with Jeff Lowe, and David Breashears filming).

The American team of Alex Lowe, Jared Ogden, and Mark Synnott climbed a long, bold, highly technical line that they called "Parallel Worlds."

The Russian team of Igor Potan'kin, Alexandr Odintsov, Ivan Samoilenko, and Yuri Koshelenko climbed an equally proud route (Eclissi) and encountered similar technical challenges.

[9] On 9 May 2024, Chantel Astorga, Christina Lustenberger and Jim Morrison made the first ski descent of Great Trango Tower via the west face.

[11] Over 7 days in August 2005, two Slovak climbers, Gabo Cmarik and Jozef Kopold, climbed a new route, which they termed Assalam Alaikum, to the right of the Wharton/Cordes line on the south face of Great Trango.

In mid-August 2009, Alexander and Thomas Huber managed to make an all free ascent of "Eternal Flame" on Nameless Tower, with climbing up to French grade 7c+.