The Dominican monastery in Vinnytsia was founded in 1630, but several years later, during the Khmelnytsky Uprising, the monks left it and returned to the city only at the end of the century.

[1] The small size and poverty of the community became the official reason for its liquidation in 1832, during the dissolution of monasteries in the Russian partition.

In 1855, in the burial crypt of the Grocholski family, which was located in the basement of the former church, the lower church of Saints Cosmas and Damian was established, moving the remains of the founders of the Dominican monastery to a separate room in the basement and bricking them up.

It functioned until 1990, when the building was handed over by the municipal and regional authorities to the Ukrainian Orthodox Church.

On that day, the local parish was transferred to the jurisdiction of the newly formed Orthodox Church of Ukraine, as did Metropolitan Simeon, the bishop of the Eparchy of Vinnytsia and Bar.