McGriff played college football for the University of Florida, where he was a member of a national championship team.
McGriff had seventy receptions as a senior in 1998, including thirteen catches in a 222-yard performance versus the South Carolina Gamecocks.
[5] He finished his final college season with ten touchdowns and an SEC single-season record of 1,357 yards receiving, and was a first-team All-SEC selection and a third-team All-American.
McGriff was chosen in the third round (ninety-third pick overall) of the 1999 NFL draft by the Denver Broncos.
He compiled 158 receptions for 2,290 yards and forty-five touchdowns in Arena Football League play.