Erik Valkendorff, a relative of the later stadtholder Christoffer Valkendorf, acquired a property at the site in the middle of the 16th century.

The hotel was also frequented by young theologians from the provinces who had come to Copenhagen with the ambition of obtaining employment at one of the city's churches.

Ane claimed to have connections in the right circles and operated a lucrative business conveying bribes that were supposed to improve the aspiring priests' chances.

In 1725, Ane was arrested and sentenced to time in the notorious Spinning House in Christianshavn while her husband was thrown out of Copenhagen.

A 15-year-old C. E. F. Weyse stayed at Tre Hjorter when he first came to Copenhagen from Altona and resided there until the composer Abraham Peter Schultz offered him accommodation in his apartment in Bredgade.

The tenants in the new building included a photographer, an importer a men's hats, a manufacturer of blinds and a book printer.