[4] After Brown displayed his skills at the junior college level, where he was named a second team NJCAA All-American in 2012, Brown was recruited by several NCAA Division I schools, including Arizona, Arkansas, Florida State, Georgia, Kansas, LSU, Oklahoma, Ole Miss, Mississippi State and Texas A&M.

[5] Brown eventually chose to continue his college career at the University of Florida, signing a National Letter of Intent in December 2012 and enrolling in May 2013.

[8] At the beginning of his first year at Florida, Brown was used mainly on field goals and "Jumbo" packages in short yardage situations.

He took over the starting tackle job in the Georgia game after Tyler Moore was injured and lost for the year.

After being asked in a 2016 interview to name the blocker that gives him the most trouble, then Denver Broncos linebacker and Super Bowl 50 MVP Von Miller said, "I feel like Trent Brown has a very bright future in the National Football League.

"[12][13][14] On August 16, 2017, Miller made a similar remark about Brown to the San Francisco Chronicle after the Broncos and 49ers had a joint practice, stating: "He's the best right tackle in the National Football League!

[18] His arrival was part of Patriots head coach Bill Belichick's attempt to build one of the heaviest rosters for a power-running offense.

With Brown, the Patriots reached and went on to win Super Bowl LIII against the Los Angeles Rams.

Brown suffered a calf injury in Week 1, missed the next three games, and was placed on injured reserve on October 9.