[8] In the College Football Playoff National Championship, he had three receptions for 81 yards in the 44–16 victory over Alabama.

[10] In his junior season, Higgins had 1,167 receiving yards and 13 touchdowns as his team finished with a 14–1 record, making it all the way to the National Championship, which Clemson lost to LSU by a score of 42–25.

[11][12] Higgins decided to forgo his final year of eligibility and declare for the 2020 NFL draft.

[17] On July 28, 2020, Higgins signed his rookie deal, a four-year contract worth $8.6 million.

[19] In Week 2, he recorded his first three professional receptions for 35 yards against the Cleveland Browns on Thursday Night Football.

[20] In Week 3, against the Philadelphia Eagles, Higgins had five receptions for 40 yards and his first two professional receiving touchdowns in the 23–23 tie.

[25] The record was broken the following year by rookie wide receiver Ja'Marr Chase, with 81 receptions.

[31] In the Divisional Round against the Tennessee Titans, Higgins recorded 7 receptions for 96 yards in the 19–16 win.

[33] In Super Bowl LVI, Higgins scored the Bengals' first touchdown of the game, a 6-yard pass from Joe Mixon.

[41] In a Week 17 game against the Buffalo Bills, after making a catch near midfield, Higgins was tackled by Damar Hamlin.

[55] During the Bengals' Week 17 loss against the Kansas City Chiefs, Higgins re-aggravated his previous hamstring injury, leading to him being ruled inactive for the final game of the season against the Cleveland Browns.

[56] He finished the season with career lows in all major statistical categories, with 656 yards on 42 receptions and five touchdowns.

Higgins had two touchdowns and 83 yards on nine catches in the Bengals Week 5 loss to the Baltimore Ravens.