Triazofos has been registered in the Federal Office of Consumer Protection and Food Safety since 1975 [1] and authorized as an insecticide in the EU until 31 December 2004 (Commission Regulation No 2076/2002).

A method of manufacturing triazofos produces the substance in the presence of triethylamine by reacting 1-phenyl-3-hydroxy-1H-1,2,4-triazole suspended in acetone with diethoxythiophosphoryl chloride.

[4] An improved process for manufacturing triazofos uses phase transfer catalyst to achieve higher yields and purity.

By comprising substituted 1-phenyl 3-hydroxy-1, 2, 4-triazole with 0, -diethylthiophosphoryl chloride in the presence of acide scavengers and 0.2% to 2.0% phase transfer catalyst at a temperature between 20-45 degrees Celsius in a suitable solvent like water.

The chemical compound is susceptible to highly toxic and flammable phosphine gas formation in the presence of strong reducing agents (such as hydrides).

23 female Wistar (WISKf (SPF 71)) rats were given triazofos labelled at the 3 position (radiochemical purity, 98%) as a single oral dose of about 5 mg/kg bw in sesame oil by gastric intubation.

Unchanged triazofos was not detected in the urine, and quantities of radioactivity in the faeces were too low for defining of the chemical species.

The metabolic fate of triazofos was also examined in two female beagle dogs, with the same treatment and sampling regimen as for rats.

The signal of oral poisoning similarly happen in mice, rats and dogs, characterized by tremors, abdominal position, squatting, jerky respiration, lachrymation, salivation, saltatory spasm, tonic convulsions.

[9][10] Triazofos interacts with several enzymes and signalling pathways according to various bio-assay results:[11][4] The use of triazofos as an insecticide in many Asian countries such China, India and Indonesia is widely known due to many insects and pests playing important roles in the market production of staple plant food production.

[12] Among various constraints, leafhoppers (Amarasca devastans) and whiteflies (Bemisia tabaci) are one of the major factors in cultivation problems due to their capability to suck the cell sap of plants.

[13] The visual observations were also constructed in assessing phytotoxic symptoms such as injury on leaf tips or surface, wilting, etc.

(See Table 2 and 3) Acute exposure to triazofos may produce the following signs and symptoms: sweating, blurred vision, headaches, dizziness, profound weakness, muscle spasms, seizures, coma, mental confusion and psychosis, excessive salivation, nausea, vomiting, anorexia, and diarrhea.

The organophosphate pesticide contains material with cholinesterase inhibitor which corresponds to the acts on the central nervous system.