[1] Trichocereus uyupampensis grows shrubby with several branches 1–2 m long, 4–8 cm diameter turning gray green with age.

From them spring eight to ten irregularly arranged spines, which are thickened at their base.

The funnel-shaped, pale yellow to white flowers are reddish on the outside, 13–19 centimeters long, opening at night time.

The specific epithet uyupampensis refers to the occurrence of the species near Uyupampa in the Arequipa region of Peru.

Heimo Friedrich and Gordon Douglas Rowley placed the species in the genus Echinopsis in 1974.