[5] In 1903 the name trichohyalin was assigned to the granules of the inner root sheath (IRS) of hair follicles discovered by Hans Vörner.

[9] Gene orthologs were identified in most mammals including mice, chickens, rats, pigs, sheep, horses and other species.

[11] Overall, trichohyalin confers mechanical strength to the hair follicle inner root sheath and to other toughened epithelial tissues.

It is a monomer, containing 1943 amino acids,[14] and has elongated (>200 nm) single-stranded alpha-helical conformation based on its unusually high content of charged residues.

[14][15] TCHH protein is extensively cross-linked to itself in the IRS tissue as well as to keratin intermediate filaments (KIF).

[19] A weak expression of the protein was discovered in the horny layer of psoriasis, ichthyosis, keratosis pilaris, porokeratosis, chronic dermatitis and callus.