Trikala (Greek: Τρίκαλα) is a town in the eastern part of Imathia, Greece.

The origins of Trikala can be traced back to the late 18th century.

The original name of the town, before the first refugees from Northern Thrace in Bulgaria arrived in 1925, was Karyes (meaning walnut trees), the current name, Trikala, means "thrice good".

Trikala was in Ottoman Empire until the Balkan Wars of 1913, afterwards, it became part of Greece.

The majority of the population of Trikala to this day is made up by immigrants arriving from the Northern Thrace[2] region of Bulgaria after a mutual population exchange between the two countries and their descendants.