Trimetrexate is a quinazoline derivative.

It is a dihydrofolate reductase inhibitor.

[1] It has been used with leucovorin in treating pneumocystis pneumonia.

[3] It is a methotrexate (MTX) analog that is active against transport-deficient MTX-resistant tumor cells that overcome the acquired and natural resistance to methotrexate.

This antiinfective drug article is a stub.