Construction began in 1838 and the church opened in 1839 in Gardiner Street Dublin.
Thomas Preston Ball(c.1825-1913) served as Chaplain of Trinity Church, Dublin, from 1879 to 1884.
John Olphert Gage Dougherty served as Rector of Trinity Church, Dublin, from 1902 to 1904.
George Howard, 7th Earl of Carlisle, attended services in the Church as did the future provost of Trinity College John Pentland Mahaffy.
[7] Since 2015 the charity ACET which assists those living with HIV are hosted by the church at the exchange building.
Many of the lessons and sermons from the meetings are available to download from the "Trinity Radio" on the website and via iTunes.