It one of the largest extant 18th century New England churches and has been designated a National Historic Landmark since 1968.

It is believed to be the only church building with its three-tiered wineglass pulpit remaining in its original position in the center of the aisle, in front of the altar.

In 1733, Dean George Berkeley donated the first organ, whose wooden case, decorated with the Crown of England and the mitres of the archbishops of Canterbury and York, survives in place.

The Chevalier de Ternay, the French admiral who died in December 1780, is buried in the churchyard.

The burial service for former Rhode Island Senator Claiborne Pell was held at the church in January 2009.