[4] Individuals with trisomy 8 mosaicism are more likely to survive into childhood and adulthood and exhibit a characteristic and recognizable pattern of developmental abnormalities.

Common findings include stunted psychomotor development, moderate to severe intellectual disability, variable growth patterns which can result in either abnormally short or tall stature, an expressionless face, and many musculoskeletal, visceral, and eye abnormalities, as well as other anomalies.

[6] The type and severity of symptoms are dependent upon the prevalence of the affected cells and their location within the body.

[citation needed] Trisomy 8 mosaicism affects wide areas of chromosome 8, containing many genes, and can thus be associated with several symptoms.

The simplest and easiest way to detect trisomy 8 is by a karyotype, a photograph representing all chromosomes of a cell in an orderly manner.