[5][6] It is a member of the TIS11 (TPA-induced sequence) family, along with butyrate response factors 1 and 2.

[7] TTP binds to AU-rich elements (AREs) in the 3'-untranslated regions (UTRs) of the mRNAs of some cytokines and promotes their degradation.

For example, TTP is a component of a negative feedback loop that interferes with TNF-alpha production by destabilizing its mRNA.

[8] Mice deficient in TTP develop a complex syndrome of inflammatory diseases.

These interactions and, possibly, interactions with target mRNAs are affected by the phosphorylation state of TTP, as the protein can be posttranslationally modified by a large number of protein kinases.