AU-rich element

[3][2] ARE-directed mRNA degradation is influenced by many exogenous factors, including phorbol esters, calcium ionophores, cytokines, and transcription inhibitors.

These observations suggest that AREs play a critical role in the regulation of gene transcription during cell growth and differentiation, and the immune response.

This lies within a 50–150 base sequence, repeats of the core AUUUA element are often required for function.

[7] HuD (also called ELAVL4) binds to AREs and increases the half-life of ARE-bearing mRNAs in neurons during brain development and plasticity.

[8] AREsite—a database for ARE containing genes—has recently been developed with the aim to provide detailed bioinformatic characterization of AU-rich elements.

[12] Alternatively, HuR proteins have a stabilizing effect—their binding to AREs increases the half-life of mRNAs.

Proposed ARE Element Mechanism.
The proposed mechanism for which ARE elements function & control sequencing.