Trout Creek is a 51-mile (82 km) long tributary of the Deschutes River in the U.S. state of Oregon.

Arising in the Ochoco Mountains, it flows north and then west to its confluence with the Deschutes River.

The creek turns northwest and then west near the ghost town of Ashwood, straddling the Jefferson/Wasco county line.

The first European Americans to arrive in the area were fur traders in the 1820s, including a group led by Peter Skene Ogden.

The Ashwood post office opened in 1898, and it quickly expanded as silver and cinnabar mines operated in the area.