Tsimiski Street (Greek: Οδός Τσιμισκή, Odós Tsimiskí) is a major avenue in Thessaloniki, the second-largest city in Greece.

[1] In 1913, when the city was in Greek hands, the street was then renamed after Ioannis Tsimiskis, a Byzantine Emperor notable for his struggles against Bulgarians.

[1] The choice of name was the result of Greek-Bulgarian tensions at the time in regards to who would eventually win the city of Thessaloniki after the Balkan Wars.

The buildings along Tsimiski street house many of the city's major offices, ranging from financing, advertising, law and engineering firms.

Tsimiski street was designed as a four-lane one-way avenue that crossed the entire length of the city center of Thessaloniki.