Tsitsamuri (Georgian: წიწამური) is a small village outside Mtskheta, Georgia.

It is known as the place where the nation's famous writer and poet, Ilia Chavchavadze, was assassinated in 1907.

Near Tsitsamuri (identified as the Seusamora of Strabo) a ruined acropolis of ancient Iberia was unearthed by the archaeologist Andria Apakidze in 1953.

It is to be identified with the Zaden-tsikhe (ზადენციხე), i.e., "the fortress of Zaden" of the medieval Georgian chronicles.

This fortress and a possible pagan temple was overlooked by Mount Zedazeni ("Upper Zaden") where later a Christian monastery was built.