Spanish Colonial Revival elements include the stuccoed brick walls, red clay roof tiles, and colorful, decorative tilework in the waiting room.

[3] The station and other railroad buildings are included as contributing resources to the National Register-listed Tucson Warehouse Historic District.

[6] Tucson station is a proposed endpoint for planned train service to Phoenix.

The Wyatt Earp and Doc Holliday statue near the train depot commemorates the revenge killing of Frank Stilwell.

Earp, Holliday, and the others pursued Stilwell along the train tracks, eventually catching and killing him.