[6][7] Composer Henry Purcell lived on or near the street (in addresses then known as St Anne's Lane from 1682 and Bowling Alley East from 1684 until 1692).

[10] No 7 Tufton Street is Faith House, designed by Sir Edwin Lutyens as the Church Institute for St John's, Smith Square and built in 1905–07.

[15] No 24 Tufton Street is Mary Sumner House, the headquarters of the Mothers' Union, a worldwide Anglican women's organisation, named after its founder.

[16] Next to it to the south is the back of a large red brick church (fronting onto Marsham Street) designed by Sir Herbert Baker and A. T. Scott in 1928 for Christian Scientists.

[17] The Tufton Street drill hall is a former military installation, designed as the headquarters of the 23rd Middlesex Rifle Volunteer Corps and completed in 1899.

[18] Eleanor Rathbone, independent member of parliament and pioneer of family allowance and women's rights, lived at Tufton Court (No 47) between 1940 and 1945.