The TNPRC is situated in 500 acres of land in Covington, Louisiana, and originally opened as the Delta Regional Primate Center in 1964.
[3] In addition to its research facilities, the center has an on-site, 40,000-square-foot (3,700 m2) Biosafety Level 3 biocontainment laboratory.
[10] In September 2014, a USDA inspection report revealed that several of the animal cages had been kept in unclean and unsanitary conditions.
[11] In November 2014, three macaques in the TNPRC's breeding colony were affected by a biosecurity breach due to staff members not following proper procedure.
[12] In September 2015, a USDA inspection revealed that personnel at the TNPRC were not following appropriate procedures regarding the criteria for euthanizing animals.