[1] Tullio DeSantis began his career as a conceptual artist/writer by creating his regular column titled MINDSTREAM, which appeared in the underground press periodical, The Rip Off Review of Western Culture.

Tullio's career as an exhibiting artist began before his graduation and continued in San Francisco through 1979, after which he moved back to the East Coast.

DeSantis moved back to the East Coast and took up dual residencies in Reading, Pennsylvania, and New York City, where he maintained a studio in Chelsea.

DeSantis's work from that exhibit included a series of color photographs and artifacts documenting the process of growing mushrooms for the commercial market, artworks on paper and a large acrylic-and-sand painting.

The artist's exhibits from the 1990s include 1992's his Reading Lies part IV: Across the You-Niverse, a multi-media installation and performance piece hosted by the Freedman Gallery of Albright College.

This was followed another gallery-size multimedia installation, DeSantis' one-person show at the New Arts Program gallery in Kutztown, Pennsylvania, titled The Missing Link.

This magical-realist environment contained, among many interactive components, miniature reconstructed and painted electric trains, papier-mâché landscapes, and a multicolor and infrared light show recreating scenes seen during morning, afternoon, sunset, and night.

This endeavor was analyzed and interpreted by Nick Mamatas in the NYC newspaper, the Village Voice in October, 2000, in an article titled All Hands Off The Keyboard.

[12] This collaborative Internet project is also represented online in the Irish Museum of Modern Art Net Open exhibitions from 2002 and 2003.

The artist's collaborative work is referenced by the New York new art foundation, Franklin Furnace and the CYBERARTS99: International Festival of Digital Media.

Additionally, Tullio DeSantis contributed a statement to Frank Moore’s book, The Uncomfortable Zones of Fun: The Temescal Period 2009-2013, which can be found on page 701.

[15] In 2006, the artist executed the initial work in a series of identity-based conceptual projects for the new millennium at The New Arts Program in Kutztown, Pennsylvania,.

DeSantis' discusses his conceptual work and his relationship with Keith Haring in a series of YouTube videos, produced by Ron Schira.

1948) exhibited Nothing as Art – a text, displayed in black inkjet toner on a sheet of white photocopy paper push-pinned to the gallery wall, which declared that not only was the formal manifestation of an idea unnecessary, but so was the idea itself.” – Andrew Marvick [Andrew Kent-Marvick], Un Coup de dessin: Looking at the Blanks in Mallarme and Khnopff.

[24] In 2016, Tullio's artwork - "Brain and Mind" serves as the Cover Illustration for Biological Psychiatry: Cognitive Neuroscience and Neuroimaging Volume 1, Issue 1 [25] The cover image can be seen here: [4] Tullio's collaborative projects in the new decade include working with artist George Blaha,[26] artist/musician Heidi Harris, MaCu(Susanne Hafenscher),[27] writers Jan Walls,[28] Leanne Ogasawara(Tang Dynasty Times),[29] and Robert Burton(Awakening Arts Network).

[30] In 2011, Dr. Tom Fink and Tullio DeSantis created MindReflector Technologies, LLC to produce neurofeedback software and mind-training applications.