[1] Prior to his appointment to his current position, he served as the Director of Industry Affairs and Content (Economic Affairs) at the Uganda Communications Commission (UCC).
[2] Twinemanzi was born in Kabale District, Uganda, into an affluent family.
Twinemanzi's mother, Christine Nyarubona, hails from the Bunyoro sub-region.
[2] Twinemanzi, obtained a Doctor of Philosophy degree in Economics from the University of Texas at Dallas, awarded in 2009.
[2] At the time of his appointment to head the bank supervision directorate at the Bank of Uganda, Dr Twinemanzi had over 15 years of experience in middle and senior management.