The Tupungato River (in Spanish: Río Tupungato) is a river located in the western zone of the Mendoza Province called Uco Valley (in Spanish: Valle de Uco), flows in Luján de Cuyo and Tupungato departments, to the west of Argentina.

It arises on the Del Plomo and Del Juncal glaciers in the north of the Tupungato Mountain and ends at the Mendoza River.

The Tupungato is a dangerous river specially from November to March (around the summer), when the ice begins to melt and increases its force.

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