After the transplant, Sheila extols the beneficial health effects of the procedure to her friends Laura Tucker, Harriet Biggle, and Linda Stotch, much to the embarrassment of her sons.
Harriet goes to Kyle and offers to give him a copy of Star Wars Jedi: Fallen Order if he procures a stool sample from Sheila.
Stan, Cartman, and Kenny sneak into the Broflovskis' basement and access the soil pipe while Sheila uses the toilet, stealing her feces, much to the anger of Kyle, who catches them in the act.
Kyle consults his doctor to complain about microbiome swapping, and wonders if people with ideal health profiles like Tom Brady will become targets of those wanting such transplants.
The boys are confronted by school counselor Mr. Mackey, who offers to buy each of them their own separate copy of Fallen Order if they obtain for him someone else's stool sample, which he also calls "The Spice Mélange" in his inner dialogue.
At another shared meal, Harriet, ill and covered in vomit stains, confronts her friends and angrily accuses Sheila of tainting her feces in some way to sabotage her transplant.
As Hell's Pass Hospital fills with local citizens suffering from C-diff, a doctor tells police detective Harrison Yates that the outbreak began at the restaurant where patrons became infected by Sheila's friends.
In addition to using music from the soundtrack, the inner dialogue used by many of the characters is a reference to the 1984 film adaptation of the novel, where it was used for direct exposition to the audience to help drive the plot and thus shorten the running time.
By combining a classic format with hilarious poop jokes and the most bizarrely entrancing Dune parody imaginable, this episode hits all the right notes.