Turtle Creek begins in a valley near Lee Road in Conyngham Township.

It flows west-southwest for approximately a mile and a half (2.5 kilometers) alongside Lee Road before passing through a pond or small lake and enters Mocanaqua.

In Mocanaqua, the creek continues flowing west-southwest for a few tenths of a mile before turning northwest.

[1] Turtle Creek joins the Susquehanna River 171.70 miles (276.32 km) upriver of its mouth.

[1] The surficial geology in the vicinity of the upper reaches of Turtle Creek mostly features bedrock consisting of sandstone and shale.

[4] The mouth of the creek is in the United States Geological Survey quadrangle of Shickshinny.

[8] Turtle Creek was entered into the Geographic Names Information System on August 2, 1979.