Written alongside Keityn and producer Ovy on the Drums, the song was released on November 7, 2019 by Universal Music Latino and Republic Records, as the lead single from Karol G's third studio album KG0516 (2021).

Elsewhere "Tusa" landed at the number one spot in over 20 countries such as, Bolivia, Colombia, Costa Rica, El Salvador and Mexico.

[6] The word tusa is Colombian slang for someone's heartache and feeling of incapability to overcome their ex-partner, accompanied by a desire for revenge.

"[9] In an interview with Billboard Giraldo revealed how Nicki Minaj's verse came to be: She called me and said: "I'm going to make the best rap of my life for your song", I felt so happy.

It became Minaj's sixth entry on the Hot Latin Songs chart, and her second top 10, following 2017's "Krippy Kush" remix with Farruko, Bad Bunny, 21 Savage and Rvssian.

"Tusa" also debuted at 56 and later peaked at number 41 on the Rolling Stone US Top 100 Songs chart on the week ending 30 January 2020, with 67,200 sales plus track-equivalent streams.

[19] On February 19, 2023, Karol G was the headlining act for Viña Del Mar International Song Festival, where "Tusa" was performed.

Nicki Minaj performed "Tusa" multiple times during the Pink Friday 2 World Tour, although it was not present on the main set list.