In the 1989 box office hit[2] Look Who's Talking, Caplan played the flirty best friend of Kirstie Alley, the female lead.
In 2007 she produced the romantic comedy I Could Never Be Your Woman, also appearing in the film as Michelle Pfeiffer's costume designer, Sissy.
Caplan played the Home Economics teacher in the television series Fast Times, with Courtney Thorne-Smith, Patrick Dempsey, and Wallace Langham.
In The New Homemakers Guide (1988), she played against Ronald Reagan Jr.; she worked with Bonnie Hunt as the nosy neighbour duo living next door to Demi Moore and Judge Reinhold.
Caplan played B. Lawney, a waitress with Richard Gere in The Flock (2007), directed by Andrew Lau; Mary Benett, a hard-edged bus driver in CSI: Crime Scene Investigation; and a past-her-prime movie star desperate for a comeback in Secrets of a Hollywood Nurse.