On July 30, 1897, Henry C. Glover platted a town in the Methow Valley he called Gloversville, in which a small store and post office were soon established.

[5] Twisp soon contained a population of miners and ranchers who were supported by many local businesses, including a drug store, a bank, a hotel, two saloons and a Methodist church.

[5] The Methow tribe was also a common sight, who continued to camp in their traditional sites and traded with the settlers.

[5] One of the first issues the five-member town council faced was liquor licenses for the two saloons, and a 1910 election was held to determine whether Twisp would implement Prohibition.

[5] The saloons served free drinks on election day, which allegedly all 88 voters partook in, and Prohibition was rejected by a vote of 56–32.

[5] Only the Filer and McAlister grocery store and the Commercial Bank's vault survived within the fire zone, which were both built of red brick.

[7] By the early 1940s, logging was a large business in Okanogan County and Ernest and Otto Wagner, a father and son team, owned the second largest operation.

[5] The opening of the North Cascades Highway in 1972 brought an influx of full-time resident retirees and seasonal recreationalists, which led to an increase of jobs.

[7] In 2009, the vacant ranger station in Twisp was converted to a campus (entitled TwispWorks) where local businesses, community organizations, artists and producers could operate.

[10] According to the United States Census Bureau, the town has a total area of 1.18 square miles (3.06 km2), all of it land.

[15] Twisp is located within Okanogan County in Washington's 4th congressional district, represented by Republican Dan Newhouse, who was sworn in on January 3, 2015.

The Town of Twisp is served by the Methow Valley School District, which includes Methow Valley Elementary and Liberty Bell Junior-Senior High School, both of which are located midway between Twisp and neighboring Winthrop.