In most cartoons, they are paired with Mickey Mouse, or most often, Pluto and Donald Duck, whom they usually battle when they see an activity they do out of curiosity or when they try to get food without getting caught by them.

The duo was nominated for the Academy Award for Best Animated Short Film three times in four years: in 1946 for Squatter's Rights (against Mickey and Pluto), in 1947 for Chip an' Dale and in 1949 for Toy Tinkers (both against Donald Duck).

In the 1980s, they became the lead characters of a half-hour television series, Chip 'n Dale: Rescue Rangers, in which they have adventures as leaders of a detective agency.

[8] In 1989, Chip and Dale became the title characters in a new animated television series, Chip 'n Dale: Rescue Rangers, in which they formed a detective agency with new characters created for the show: female mouse inventor Gadget Hackwrench, muscular adventuring Australian mouse Monterey Jack and Zipper the fly.

[9] In this series, the personality differences between the two are more pronounced, with Chip as the serious, heroic leader and Dale as the quick-witted, hard partying reluctant hero.

Chip 'n' Dale, based on their Rescue Rangers iterations, made an appearance in the 2017 TV series DuckTales.

[12] Chip 'n Dale star in a CGI preschool short series, spin-off of Mickey Mouse Mixed-Up Adventures.

[15] The series portrays Chip 'n' Dale's adventures living in a park where they often interact with Clarice, Donald Duck, Pluto, and other mostly Duckburg-centric Disney characters.

A hybrid live-action/animated film, Chip 'n Dale: Rescue Rangers, was released on May 16, 2022, with animation of the characters provided by Moving Picture Company and their voices by John Mulaney and Andy Samberg.

[17] The classic voices of Chip 'n' Dale were mostly provided by Jimmy MacDonald, Dessie (Flynn) Miller and Helen Silbert.

John Mulaney and Andy Samberg voiced the two in the Chip 'n Dale: Rescue Rangers live-action film.