The Tylihul (Ukrainian: Тилігул) is a river in the Odesa Oblast of southern Ukraine.

Its source is in the Podilian Upland and it flows through a narrow (1.0—1.5 km wide) valley to the Black Sea depression, where the valley widens up to 3 km.

The river inflows to the Tylihul Estuary.

The name of the river comes from the name of the water body into which it flows, the Tylihul Estuary, Turkish: Deli Göl, which means "mad or rabid lake".

This article related to a river in Ukraine is a stub.