The character was initially depicted as an enemy of Daredevil suffering from dissociative identity disorder, but has also come into conflict with Spider-Man and Deadpool, ultimately marrying the crime boss the Kingpin (Wilson Fisk), as his second wife.

Alice Eve portrayed the character in the second season of the Marvel Cinematic Universe television series Iron Fist (2018).

The character first appeared disguised as Mutant Zero in Avengers: The Initiative #4 (September 2007) as a member of Henry Peter Gyrich's black ops team.

People who don't even follow comics regularly will know who it is.Typhoid Mary is an enemy and former lover of Daredevil with low level psionic powers, including telekinesis.

[volume & issue needed] [6] Suffering from dissociative identity disorder, Mary Walker has three other abnormal personalities in addition to her seemingly healthy one.

Aside from highly developed martial arts skills, she also possesses telekinetic powers and, more dangerously, pyrokinesis, the ability to ignite people or objects in her vicinity.

[10] She hires Bullet, Bushwacker, Ammo, and the Wild Boys to attack Daredevil,[11] and then personally led these criminals against the blind vigilante.

Through hypnosis, the abnormal and psychotic personalities were suppressed from Walker's consciousness, and she began to lead a normal life, becoming an actress on a soap opera.

[volume & issue needed] She was sent by Doctor Doom to learn the secrets of Kymellian technology from Power Pack during the Acts of Vengeance.

[18] Following a series of events involving the Kingpin (fall from power, subsequent near-death coma, recovery, rising back to power, and taking out enemies to retake the criminal empire),[19] the Kingpin distracts Daredevil by paying a visit to Walker at her show and, with a blunt slap, released the abnormal personalities.

Murdock's bodyguards Luke Cage and Jessica Jones managed to take her down after she confronted Daredevil's secret identity and set the man on fire.

[21] At some point after the superhuman Civil War's events, she is found and recruited into Henry Peter Gyrich's Initiative program as "Mutant Zero", although her true identity was kept secret from her teammates.

[24] During the Shadow Initiative's fight against HYDRA, Mary loses control of her personalities, having spent too much time from the Zero Room, and flees.

[25] During the "Shadowland" storyline, Mary answers Daredevil's call for superheroes to join The Hand in providing martial law for an ever-increasing area of New York City.

She can use telekinesis to levitate small objects over short distances (such as weapons of under 10 pounds; knives, razors, etc., which her "Bloody Mary" persona often gathered and assembled into improvised battle-armor).

She is a powerful pyrokinetic, meaning she can cause spontaneous combustion within line of sight to set objects in her immediate vicinity aflame.

Mutant Zero is also equipped with a suit of full body armor that appears to enhance her physical strength and an arsenal of weapons, including guns and various blades.