Tyrone Anthony Holmes (born September 10, 1993) is an American former professional football linebacker.

Holmes was selected by the Jacksonville Jaguars in the sixth round with the 181st overall pick in the 2016 NFL draft.

[9] On December 14, 2017, Holmes was signed to the Kansas City Chiefs' practice squad.

[12] In December 2018, Holmes signed with the San Antonio Commanders of the Alliance of American Football (AAF) before departing the team to join the Los Angeles Chargers practice squad.

[14] After the AAF suspended football operations, Holmes signed with the Miami Dolphins on April 9, 2019.