Poole has also played for Indianapolis Colts, Denver Broncos, New England Patriots, Oakland Raiders and Tennessee Titans.

Poole was as a four-year starter at Fort Valley State University and became the first player from that school to ever be selected in the first round of the NFL draft.

Poole was selected by the Carolina Panthers in the first round (22nd overall) of the 1995 NFL draft out of Fort Valley State University.

Poole was a starting cornerback for the Patriots defense that led them to a 14–2 record and a victory in Super Bowl XXXVIII over the Carolina Panthers.

Poole returned briefly for a few snaps near the end of a Week 14 game against Cincinnati, but was shut down after this and did not play again for the rest of the season.

Poole was signed by the Tennessee Titans on November 22, 2008, after cornerbacks Reynaldo Hill and Eric King were placed on injured reserve.