U.S. Highway 10 (US 10) in North Dakota runs 8.042 miles (12.942 km) from Interstate 94 (I-94)/US 52 near West Fargo east through Fargo before crossing the Red River of the North and entering Moorhead, Minnesota.

US 10 serves as a primary east–west corridor through the Fargo–Moorhead (Main Avenue) and is concurrent with I-94 Business for its entire length in North Dakota.

East of this interchange, US 10 loses its median but remains two lanes each direction after intersecting 25th Street.

After this intersection, US 10 curves slightly southeast and runs along the Northern Transcon railroad tracks, heading into downtown.

At the east end of downtown Fargo, US 10 intersects 2nd Street at a roundabout before crossing over the Red River of the North and into Moorhead, Minnesota, on the Veterans Memorial Bridge.