U.S. Route 150 (US 150) in Kentucky is a 121.097-mile-long (194.887 km) east–west highway that runs from the Indiana state line above the Ohio River to US 25/KY 1249 at Mount Vernon.

Starting on the Sherman Minton Bridge over the Ohio River, I-64 and US 150 enter the city of Louisville.

Just west of the Cave Hill Cemetery, US 150 turns southeast along US 31E (Baxter Avenue).

The road reaches the city limit of Louisville shortly after intersecting with KY 660.

[2] After leaving Louisville and Jefferson County, US 31E/US 150 begins to bypass downtown Mount Washington.

Just before intersecting with KY 44, the road downgrades to a four-lane undivided highway.

In Stanford, the route intersects with US 27 before returning to a two-lane undivided road.