After going through Livingston and Mount Vernon, US 25 continues to run northward, passing through Berea.

US 25 then meets US 421, which begins a long concurrency with US 25, and the two routes go around Richmond on a bypass.

North of Richmond, US 25/US 421 runs concurrently with I-75 to cross the Kentucky River.

The highway continues through Corinth, Williamstown, Dry Ridge, Crittenden, and Walton.

In Covington, the three routes begin to cross the Ohio River on the Clay Wade Bailey Bridge.