US-56 west of Sublette US-54 from Plains to Meade US-281 in Medicine Lodge US-81 in Wellington I-35 / Kansas Turnpike US-77 in Winfield US-75 in Independence US-59 in Oswego U.S. Route 160 (US-160) is a part of the U.S. Highway System that runs from US-89 near Tuba City, Arizona east to US-67 and Missouri Route 158 southwest of Poplar Bluff, Missouri.

At Columbus, US-160 begins a concurrency with U.S. Route 69, which goes east to Crestline, then north to Frontenac, Kansas.

Also at Crestline, it picks up a second concurrency with U.S. Route 400, which goes north and ends just south of Pittsburg, Kansas.

The section of US-160 in Harper, from K-14 to slightly east of end of overlap with K-2 is maintained by the city.

Then in a December 9, 1998 resolution, US-160 was realigned over K-96 from US-169 east to US-69 Alternate then turned north toward Pittsburg.