U.S. Route 183 (US 183) is a north-south U.S. highway that begins in Texas in Refugio at an intersection with US 77 (Future I-69E) concurrent with US 77 Alt.

Running parallel to the San Marcos River, US 183 provides access to Palmetto State Park before crossing I-10 and forming a concurrency with US 90 west to Luling via Pierce Street.

In the center of Luling, US 183 leaves US 90 and turns onto Magnolia Avenue, traveling due north past many decorated oil wells.

It eventually intersects SH 45 near Lakeline Mall and becomes a surface street while the freeway continues on the east side as 183A Toll Road.

US 183 and US 190 continue traveling northwest through rolling hills, eventually splitting southeast of the Lometa city limits.

US 183 continues to run parallel to the Colorado River before beginning a concurrency with US 84 north of the Goldthwaite city limits.

The four highways travel west for roughly eleven blocks before US 183 splits to the north and serves Brownwood Regional Airport.

The northern freeway portion between Spicewood Springs Road and Bell Boulevard in Cedar Park was completed by 2003.