US 24 then proceeds through a series of small towns; east of Camp Point, it intersects the southern terminus of IL 94.

West of Havana, US 24 joins IL 100 northbound, and US 136 westbound, forming a wrong-way concurrency.

US 136 leaves US 24 and travels west at Duncan Mills, while US 24 and IL 100 continue north to Lewistown.

The series of concurrencies ends in Little America, where IL 78 turns north and US 24 continues northeast.

US 24 leaves I-474 after three miles and enters Creve Coeur with IL 29 northbound as South Main Street.

US 24/IL 29 joins IL 8/IL 116 eastbound at the foot of the left connector ramp and then continues north.

The highway continues past Illinois Central College to the interchange of US 24 Business (US 24 Bus.)

continues to Washington's town square on a four-lane undivided surface road, which eventually narrows to a two-lane road; the US 24 bypass remains four lanes divided to Main Street north of Washington.

In Watseka, it overlaps IL 1 through the town; the final concurrency, with US 52 in Sheldon carries into Indiana.

Prior to 1937, US 24 ran through Canton on various roads; afterward, it was relocated southeast, closely paralleling the Illinois River.

Since the 1950s, US 24 through Illinois and Missouri has been considered as one route of various Chicago to Kansas City federal Interstate proposals (1956, 1968, 1972).

This highway involved new signage designating the route as IL 110 and did not require any new road construction.