), is the western half of the divided four-lane bypass, west around Statesboro, Georgia, also known as "Veterans Memorial Parkway".

), in complete concurrency with SR 121 Byp., is a divided four-lane bypass, east around Waynesboro, Georgia.

begins at an interchange with US 1/US 25/US 78/US 278/SR 10/SR 121 (Gordon Highway) on the line between the Olde Town portion of the city of Augusta and downtown.

At this intersection, SR 28 departs to the left, heading toward the Government Center and an intercity bus station.

An intersection with 7th Street leads to the Woodrow Wilson Boyhood Home and James Brown Arena.

An intersection with 12th Street leads to the Museum of Black History and Springfield Village Park.

At an intersection with SR 4 (13th Street), which leads to the Sacred Heart Cultural Center, Meadow Garden, and the Medical District, US 25 Bus.

They intersect Jones Street, which carries the eastern terminus of the eastbound lanes of SR 104.

The next intersection is with Reynolds Street, with carries the eastern terminus of the westbound lanes of SR 104.

and SR 4 encounter an entrance to the New Bartram Trail before beginning to travel over the Savannah River on the James U. Jackson Memorial Bridge.

About in the center of this bridge, SR 4 and 13th Street end at the South Carolina state line, and US 25 Bus.

Just south of an intersection with the northern terminus of Center Street, it passes the City of North Augusta Municipal Building.

An intersection with Spring Grove Avenue leads to the living history park and North Augusta Elementary School.

At an intersection with the eastern terminus of Jackson Avenue, the highway curves to the northeast.

Just north of Observatory Avenue, it passes the studio and office facility of WRDW-TV.

are part of the National Highway System, a system of routes determined to be the most important for the nation's economy, mobility, and defense: Major intersections U.S. Highway 25 Connector (US 25 Conn.) is a 0.550-mile-long (0.885 km) connector route of US 25 that is completely unsigned.

Just after this interchange, the highway begins a curve to the northwest and intersects the Palmetto Parkway Trail.

A short distance later, it very briefly cuts across part of Belvedere and then meets its northern terminus, an intersection with US 25/SC 121 (Edgefield Road).

Signage in the area shows a business banner on top of US 25, which goes through downtown Edgefield; it is in fact mainline US 25.

is a 4.310-mile (6.936 km) business route of US 25 that is partially within the city limits of Ware Shoals, South Carolina.

was established in 1968 or 1969 when US 25 was rerouted to bypass west of downtown Greenville, South Carolina.

Replacing a section of US 176, it traverses through East Flat Rock, downtown Hendersonville, and Mountain Home, North Carolina, before reconnecting with mainline US 25 near Fletcher.

It runs along the original alignment of US 25 through downtown Richmond, while US 25 proper bypasses the city to the east.