U.S. Route 287 (US-287) is a north-south highway that starts at the Texas state line north of Kerrick, Texas, and ends at the Colorado state line south of Campo, Colorado.

In Oklahoma, US-287 remains within Cimarron County, located at the end of the Panhandle.

US-287 continues northwest, crossing the Beaver River, toward Boise City.

On the east side of town, the highway crosses US-56, US-64, and US-412, and forms a concurrency with SH-3.

[2] On May 28, 2021, Oklahoma governor Kevin Stitt signed legislation designating a roughly 20-mile portion of U.S. 287 between Boise City and the Oklahoma-Texas border as the President Donald J. Trump Highway, effective as of November 1.