US 36 intersects several major highways in the state, including Interstate 75 (I-75), I-71, and I-77.

US 36 then travels north concurrently with US 127, meeting SR 49 and bypassing downtown Greenville.

Westbound US 36 traffic on that interchange briefly runs concurrently with the state route.

Between the Ohio Wesleyan University and the Olentangy River in Delaware, US 36 meets US 23/US 42, beginning a short concurrency with US 42.

[2] After leaving the downtown area of Delaware, SR 37 begins running along US 36 all the way to Sunbury.

After the latter intersection, the road curves eastward toward downtown Mt.

Southbound SR 13 travels two blocks east along the concurrency from Sandusky to Mulberry streets.

On its way to Coshocton, US 36 somewhat meanders eastward due to the Kokosing and the Walhonding rivers.

For its remainder of the route, US 36 meets Port Washington, SR 416 in Gnadenhutten, Riverside Park, and Tuscarawas.

As US 36 became an expressway bypass in Uhrichsville, US 36 ends at a parclo interchange with US 250/SR 800.