U.S. Route 40 (US-40) is a part of the U.S. Highway System that runs from Interstate 80 (I-80) and US-189 in Silver Summit, Utah east to US-322 and Ocean Drive in Atlantic City, New Jersey.

From there it goes northeast to Oakley and follows Eagle Eye Road before merging with I-70 east of town.

The two routes remain merged until Topeka, although the prior alignment of US 40, named Old Highway 40, parallels I-70 for most of the way.

At the west side of Lawrence, the route is joined by K-10 and travels south and east to the junction with US 59 and then runs north with US 59 to cross the Kansas River.

Before this date, US 40 and US 24 continued along State Avenue to College Parkway before turning right to follow Turner Diagonal for 1⁄2 mile (800 m) where US 40 joined Interstate 70 for the duration of its journey eastward toward Missouri.

By the time Barclay Avenue encounters South 13th Street, US-283 turns left to the north, US-40 Bus.

After passing by the Kansas Veterans Cemetery, and the headquarters for the Western Co-Op Electric Association,[8] US-40 Bus.

terminates at exit 128 on I-70/US-40, while South 13th Street continues as a local road that changes its name to 260th Avenue.

It ran from Exit 184 along Interstate 70/US 40, overlapping part of U.S. Route 281 (South Fossil Street) then makes a right turn onto East Wichita Avenue (old US 40).