In Sevier County, Tennessee, south of Knoxville, US 411 is used by many tourists as a route to the northern side of the Great Smoky Mountains National Park.

US 411 heads north along two-lane 9th Street, which has a pair of at-grade crossings of Norfolk Southern Railway rail lines.

Highways enter town along 5th Street and proceed to the county courthouse, where they meet the eastern end of SR 23 (6th Avenue).

US 411 follows the western flank of Dunaway mountain to Rainbow City, where the route intersects SR 77 (Grand Avenue).

The highway crosses the Big Wills Creek branch of Neely Henry Lake and meets the eastern end of I-759 at a partial cloverleaf interchange; that freeway continues east as SR 759.

The highway passes by the Spirit of American Citizenship Monument and under Broad Street, an Omnitrax rail line, and US 278 and US 431 (Meighan Boulevard), which access US 411 via a partial cloverleaf interchange.

US 411 leaves (or will soon exit) Gadsden along a newly constructed four-lane divided highway that passes between Shinbone Ridge to the west and several loops of the Coosa River.

The U.S. Highway continues as Cave Spring Road, which crosses Cedar Creek and passes through Vans Valley.

US 411 passes under the West Rome Bypass and intersects US 27 and SR 1 (Cedartown Highway), which US 411 joins heading north.

US 411 and US 27 expand to a divided highway as they enter the city of Rome and then a four-lane freeway as they cross over a Norfolk Southern rail line.

US 411 has an intersection with the southern end of SR 1 Loop (East Rome Bypass) before leaving the city limits.

US 411 crosses over an east–west CSX rail line immediately before its trumpet interchange with US 41 and SR 3 (Joe Frank Harris Parkway).

Highways head southeast into the city of Cartersville then diverge immediately to the east of a north–south CSX rail line at the boulevard's partial cloverleaf interchange with SR 61 (Tennessee Street).

US 411 drops to two lanes south of the town of White, where the highway begins to closely parallel the north–south CSX rail line.

The U.S. Highway intersects SR 140 (Henry Mack Hill Road) in the hamlet of Rydal before entering Gordon County.

The U.S. Highway passes along the west flank of Camp Ground Mountain and is named Hill Street through the town of Eton, where the route meets the eastern end of SR 286 (Coffey Road) and drops to two lanes.

US 411 passes through the town of Crandall, crosses to the east side of the railroad, and follows the Fairy Valley to the hamlet of Cisco, where SR 2 splits to the west.

US 411 then has a grade-separated interchange with its former alignment (Warren Street) before becoming undivided before leaving Madisonville and continuing north as a 4-lane divided highway through farmland and countryside.

US 411 then comes to an intersection and becomes concurrent with SR 72 (Loudon Highway) just before entering the town of Vonore (the northern terminus of the Old Federal Road) and becoming undivided once again as this time it passes straight through downtown.

US 411 continues into downtown, as Broadway Avenue, and comes to an intersection with US 321 (SR 73) (Lamar Alexander Parkway; provides access to Walland, Townsend, Wears Valley, and Great Smoky Mountains National Park).

It then passes by Blount Memorial Hospital before going through some neighborhoods before leaving Maryville and continues as a narrow 2-lane highway through countryside and farmland and crosses the Little River in the community of Wildwood.

It continues through a major business district and has an intersection with SR 449 (Veterans Boulevard; provides access to Dollywood and Pigeon Forge).

It then has an intersection with SR 339 (Long Springs Road; provides access to Cosby) before leaving Cherokee Hills and narrowing to an improved 2-lane Highway.